The antigenic index: a novel algorithm for predicting antigenic determinants

The antigenic index: a novel algorithm for predicting antigenic determinants

In this paper, we introduce a computer algorithm which can be used to predict the topological features of a protein directly from its primary amino acid sequence. The computer program generates values for surface accessibility parameters and combines these values with those obtained for regional backbone flexibility and predicted secondary structure. The output of this algorithm, the antigenic ...

A computer program for predicting protein antigenic determinants.

A computerized method for predicting the locations of protein antigenic determinants is presented, which requires only the amino acid sequence of a protein, and no other information. This procedure has been used to predict the major antigenic determinant of the hepatitis B surface antigen, as well as antigenic sites on a series of test proteins of known antigenic structure [Hopp & Woods (1981) ...

Antigens and Antigenic Determinants

Epitope:-is the unique region on an Ag that will bind a complementary Ab i.e. that portion of an antigen that combines with the products of a specific immune response. It is also called antigenic determinant. Epitopes generally are significantly smaller than the antigens which contain them (and much smaller than the size of an antibody).A single antigen often contains numerous Epitopes. Antigen...

Antigenic properties of the Fab fragment of human IgM: antigenic determinants common to IgM and IgG.

Mapping of human apolipoprotein B antigenic determinants.

A minimum of 16 epitopes which provide a group of topographical markers to study the conformation of apolipoprotein (apo) B have been mapped in relation to elements of the sequence of apo B-100. Six of these epitopes are identified by monoclonal antibodies (Mabs) directed against low density lipoprotein (LDL) apo B, while at least 10 others react with Mabs obtained by immunization with delipida...